【摘 要】
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Objetive: It is reported that cholesterol metabolism is closely related to cancer.Yet, until now, few medicine which can both lower the cholesterol level an
【机 构】
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Department of Genetics and Developmental Biology,College of Life Science and Technology,Huazhong Uni
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Objetive: It is reported that cholesterol metabolism is closely related to cancer.Yet, until now, few medicine which can both lower the cholesterol level and kill the cancer has been reported.We found that Vitamin K2 and its biosynthetic enzyme, UBIAD 1, possess both anticancer and lowering cholesterol capabilities.The goal of this paper is to study the molecular mechanism ofUBIAD1.Methods: A combination of biochemical, biophysical and cellular biology methods were deployed to study the above mechanism.Results: In normal cell conditions, UBIAD 1 is accumulated on the ER protecting HMGCoA reductase, a key enzyme in cholesterol synthesis.When adding UBIAD1, UBIAD1 is separated from HMGCoA reductase and transported to the Golgi.UBIAD1 interacts with H-Ras on the Golgi, activating the Ras signal axis, inducing the apoptosis of cancer cells.
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