Fe3O4 Magnetic Nanoparticle Peroxidase Mimetic-Based Colorimetric Assay for the Rapid Detection of O

来源 :The 9th Asian Biophysics Association Symposium (ABA2015)(第九届 | 被引量 : 0次 | 上传用户：hawk1918

【摘要】

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【作者】

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Minmin Liang Kelong Fan Meng Zhou Xiyun Yan

【机构】

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Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of S

【出处】

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The 9th Asian Biophysics Association Symposium (ABA2015)(第九届

【发表日期】

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2015年9期

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Rapid and sensitive detection methods are in urgent demand for the screening of extensively used organophosphorus pesticides and highly toxic nerve agents for their neurotoxicity.In this study, we developed a novel Fe3O4 magnetic nanoparticle (MNP) peroxidase mimeticbased colorimetric method for the rapid detection of organophosphorus pesticides and nerve agents.The detection assay is composed of MNPs, acetylcholinesterase (AChE), and choline oxidase (CHO).The enzymes AChE and CHO catalyze the formation of H2O2 in the presence of acetylcholine, which then activates MNPs to catalyze the oxidation of colorimetric substrates to produce a color reaction.

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Fe3O4 Magnetic Nanoparticle Peroxidase Mimetic-Based Colorimetric Assay for the Rapid Detection of O

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