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人脑局部场电位记录为探索脑深部核团功能提供了独特的方法。本文为研究丘脑底核局部场电位的同步化和动态稳定特性以及药物治疗对其的影响,对帕金森病患者的丘脑底核局部场电位信号进行功率谱分析、时频分析和幅度变异系数分析。结果表明,低Beta频段在不服药状态下存在明显的过度同步化,药物治疗可显著抑制该成分。此外,服药后Theta成分同步化特征显著升高且动态波动性增强,同时Gamma频段动态波动性亦显著增加。丘脑底核局部场电位在药物作用下多频段同步化与稳定性发生变化,有可能与帕金森病药物作用下异动等症状的发生有关。这些特征的发现将有助于为帕金森病的机制研究与药物治疗建立基于多特征融合的敏感和特异的神经标记物,为实现闭环深部脑刺激提供判别指标。
Local field potential recording in human brain provides a unique way to explore the function of deep brain nuclei. In this paper, in order to study the synchronization and dynamic stability characteristics of local field potentials in subthalamic nucleus and the influence of drug treatment on them, the power spectral analysis, time-frequency analysis and amplitude coefficient of variation of local field potential signals in the subthalamic nucleus of Parkinson’s disease patients . The results showed that there was a significant over-synchronization of the low-beta band in the absence of medication, and drug treatment could significantly inhibit the composition. In addition, the Theta component synchronization characteristics significantly increased and the dynamic volatility increased, while the Gamma band dynamic fluctuations also significantly increased. Local field potentials in the subthalamic nucleus vary with the frequency and stability of the multi-band drugs under the action of drugs, which may be related to the occurrence of symptoms such as dyskinesia under the action of Parkinson’s disease drugs. The discovery of these features will help to establish a sensitive and specific neural marker based on multi-feature fusion for mechanism study and drug therapy of Parkinson’s disease, and provide a marker for the realization of closed-loop deep brain stimulation.