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In this talk,the following effective computational models developed by Chen Group for the Bioinformatics research will be introduced: 1)PBMDA(PLOS Computational Biology,2017,13(3): e1005455,cited 11 times): Path-Based MiRNA-Disease Association(PBMDA)prediction model was proposed by constructing a heterogeneous graph consisting of three interlinked sub-graphs and further adopting depth-first search algorithm to infer potential miRNA-disease associations.