肠道病毒71型3C蛋白酶通过切割宿主蛋白TRAF3IP3增强病毒复制

来源 :中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 | 被引量 : 0次 | 上传用户：mnswangjian

【摘要】

：

肠道病毒71型(EV71)属于小RNA病毒科肠道病毒属成员，作为手足口病(HFMD)主要病原体之一，严重威胁公共卫生安全与婴幼儿健康.目前尚无针对EV71感染的特效治疗药物和高效疫苗.EV71的非结构蛋白3C蛋白酶除了能切割病毒多聚蛋白前体，有利于病毒自身蛋白的成熟；还能切割多种宿主蛋白，导致宿主转录和翻译的抑制，有利于病毒逃避天然免疫，促进病毒复制.3C蛋白酶连接宿主与病毒的相互作用，使其成为理

【作者】

：

李卉陈宇乔文涛谈娟

【机构】

：

分子微生物学与技术教育部重点实验室,南开大学生命科学学院,天津,300071

【出处】

：

中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议

【发表日期】

：

2018年10期

【关键词】

：

EV71 3C蛋白酶 TRAF3IP3

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肠道病毒71型3C蛋白酶通过切割宿主蛋白TRAF3IP3增强病毒复制

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