Objectives: In recent years,there are some special"patients"having been reported in China.They had displayed symptoms very similar to AIDS,but they have received many tests and ali negative.We do not think it was simply caused by mental problems.These"HIV negative AIDS"patients possibly belong in idiopathic CD4+T lymphocytopenia (ICL),which still remains a mystery to clinicians,experts and the public.So we have finished this article.Methods:All cases included in this study were found by using databases (MEDLINE,EMBASE,PubMed,Science Direct,CJFD and CNKi)search(1990-2011)of the medical literature applying the terms "idiopathic CD4+ T lymphocytopenia,""immunodeficiency,""ICL syndrome,""HIV negative",and"opportunistic infections."Results:The syndrome of ICL has a worldwide distribution and approximately half of the cases(46.26%) have been reported in America.The mean age of the patients was 38.44 years (range,2 months-78 years).The top age group was 50-.The individuals with ICL may manifest a heterogeneous group of conditions including infectious and primarily immunologic disorders.The main causes of death in patients with ICL include serious infections and acute complications.Conclusions: From the clinical and epidemiologic data available,it is simply unclear whether idiopathic CD4+T lymphocytopenia whether idiopathic CD4+T lymphocytopenia is a new clinical entity.It is also unknown is"HIV negative AIDS"groups in lymphocytopenia have same features China and caused by a transmissible agent.The patients with idiopathic CD4+T in clinical manifestations to some extent.