The aberrant carbohydrate structure expressing on the surface of cancer cells known as tumor-associated carbohydrate antigens(TACAs),provide a target for cancer vaccines.
The methyltransferase SETD7/9(SETD7)is an important therapeutic target in cancer.(R)-PFI-2 had a high affinity to hSETD7 with nano-molar IC50 values,while(S)-PFI-2 showed 500-fold less active in IC50
As an important target for potential herbicides,protoporphyrinogen oxidase(PPO,EC 1.3.3.4)is the penultimate enzyme in the biosynthesis of chlorophyll and heme,which catalyzes protoporphyrinogen Ⅸ to