Advanced glycation end products (AGEs) are a heterogeneous group of proteins that have been modified with glucose or carbohydrates adducts, and are thought to be responsible for many complications of diabetes and aging.Free amino groups of proteins react slowly with reducing sugars such as glucose by the glycation or Maillard reaction, initially forming Schiff bases, which undergo rearrangement to form the relatively stable Amadori products.The Amadori products subsequently degrade into a-dicarbonyl compounds which reacting with amino groups of proteins to form cross-links, stable end products called.AGEs have been shown to react (cross-link) with the amino group of the N-terminal amino acid residue and the side-chains of arginine and lysine residues.Therefore, glucose has been shown to be responsible, at least in part, for protein cross-linkage, oxidative stress and cytotoxicity.