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  5. MethylPurify: tumor purity deconvolution and differential methylation detection from tumor DNA methy

MethylPurify: tumor purity deconvolution and differential methylation detection from tumor DNA methy

来源 :第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会 | 被引量 : 0次 | 上传用户：lanrenlaopan
【摘 要】
：
Background: DNA methylation plays pivotal roles in gene regulation during tumor initiation and progression, and many cancer epigenetic studies have been devoted to identifying differentially methylate
【作 者】
：
Xiaoqi Zheng Peng Jiang Fuqiang Li Yong Hou Jianxing He Jun Wang Jun Wang Peng Zhang Yong Zhang X.Shirley Liu Qian Zhao Hua-Jun Wu Wei Li Haiyun Wang Clifford A.Meyer Qian Alvin Qin Han Xu Chongzhi Za 
【机 构】
：
Department of Mathematics, Shanghai Normal University, Shanghai, China;Department of Biostatistics a
【出 处】
：
第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会
【发表日期】
：
2014年4期
【关键词】
：
DNA methylation Tumor purity Heterogeneity Differentially methylated regions Mix 
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　　Background: DNA methylation plays pivotal roles in gene regulation during tumor initiation and progression, and many cancer epigenetic studies have been devoted to identifying differentially methylated regions (DMR) between tumor and its adjacent normal tissues.However, tumor impurity has been a major technical issue in tumor profiling studies, because tumor tissues often contain unknown fractions of normal cells themselves, which could bias the methylation level estimate and DMR calling.
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