Childhood or adolescent hearing loss is often inherited as an autosomal dominant Mendelian trait,representing around 20% of all cases of hereditary non-syndromic sensorineural hearing impairment (NSSHI).In a previous study,we identified a highly conserved mis-sense change of phosphatidylinositol 4-kinase beta (pi4kb),which is highly conserved in zebrafish,rat,rhesus and human,and associated with the autosomal dominant inherited non-syndromic sensorineural hearing impairment (ADNSSHI).