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5. Total Synthesis of (-)-Lycopladine D

Total Synthesis of (-)-Lycopladine D

来源 :The 24th International Society of Heterocyclic Chemistry Con | 被引量 : 0次 | 上传用户：mzhou2009

【摘 要】

：

Lycopladine D was isolated from Lycopodium complanatum by Kobayashi in 2006.[1] The total synthesis was accomplished in 15 steps with 7.2％ overall yield, which featured a stereoselective birch reducti

【作 者】

：

Chen Zeng Gang Zhao 

【机 构】

：

Key Laboratory of Synthetic Chemistry of Natural Substances,Shanghai Institute of Organic Chemistry,

【出 处】

：

The 24th International Society of Heterocyclic Chemistry Con

【发表日期】

：

2013年4期

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论文部分内容阅读

Lycopladine D was isolated from Lycopodium complanatum by Kobayashi in 2006.[1] The total synthesis was accomplished in 15 steps with 7.2％ overall yield, which featured a stereoselective birch reduction, an intramolecular mitsunobu reaction, an allylic oxidation and a biomimetic N,O-ketal bridged lactone formation.

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