Objective To explore on changes of serum sexhornone,bone mineral density (BMD) and their related factor in-patients with type 2 diabetes.Methods Eighty-nine cases of type 2 diabetes mellitus patients were divided into three group according to BMD T-core:Osteoporosis(op)group:(Tscore below-land-2.5); osteopenia group ;(T score between-land-2.5);Normal group(T score above-1).The Levels of FSH,LH,PRL,E2,T,P were measure 89 patient with type 2 diabetic mellitus and 70 nondiabetes subjects.