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Objective To observe the effects of Yi Qi Qing Re Gao (YQQRG) on intrinsic renal cell apoptosis induced by puromycin aminonucleoside.Methods Male Wistar rats were randomly divided into 4 groups: sham group, PAN model group,PAN+YQQRG group and PAN+fosinopril group, each group with 12 rats.