Omega 3 polyunsaturated fatty acids (ω3 PUFAs) such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are recognized as agonists of free fatty acid
Pulmonary arterial hypertension (PAH) is a severe and progressive disease, which is commonly associated with chronic hypoxemia in disorders such as chronic obst
Background: Failure of resolution mechanisms contribute to disease pathogenesis in non-neoplastic inflammatory diseases.Inflammation in the tumor microenvironme
Over the past decade,rapid advances in genomics,proteomics and functional genomics technologies enable in-depth interrogation of cancer genomes and proteomes,an
To obtain kilobase resolution chromatin interactions at low cost remains a major challenge.We present algorithms,named CISD and CISD_loop,to precisely identify
Structural variation (SV) is an important class of genomic variations in human genomes.Until recently,a number of SV detection algorithms based on high-throughp
Genome-wide association studies (GWAS) have been widely used in genetic dissection of complex traits.However,common methods are all based on a fixed-SNP-effect
Chromosomal rearrangement (CR) events have been implicated in many tumor and non-tumor human diseases.CR events lead to their associated diseases by disrupting
A high quality reference genome is critical for understanding genetic variation and evolution of an organism.The long reads generated from single molecule,real-