Background: The aim of our study is to evaluate the preliminary efficacy and side effects of paclitaxel,5-fluorouracil and leucovorin intravenous chemotherapy in combination with cisplatin hyperthermic intraperitoneal perfusion chemotherapy(HIPEC)as postoperative adjuvant therapy for patients of locally advanced gastric cancer(GC)who was at high risk for recurrence after curative resection in our center.