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OBJECTIVE Immunoglobulin D(IgD)is a surface immunoglobulin that is expressed as either membrane IgD(mIgD)or secreted IgD(sIgD).Researchers have shown that sIgD is often elevated in patients with autoimmune diseases.The possible roles of sIgD on the function of peripheral blood mononuclear cells(PBMCs)in rheumatoid arthritis(RA)are still unclear and few studies have been performed.