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The aberrancy of wnt/beta-catenin pathway is common in a wide variety of human tumors.Though there have been piles of work unrevealing a number of genes involved in this pathway in cancer development, the traditional gene to gene strategy failed to gain a full reflection of the changes responding to abnormal wnt/beta-catenin pathway.The aim of this study is to identify unknown targets or signal transduction pathways that are regulated by wnt/beta-catenin pathway.