【摘 要】
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Both adoptive immunotherapy and gene therapy hold a great promise for treatment of malignancies.However, these strategies exhibits limited anti-tumor activity, when they are used alone.In this study,
【机 构】
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Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical Unive
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Both adoptive immunotherapy and gene therapy hold a great promise for treatment of malignancies.However, these strategies exhibits limited anti-tumor activity, when they are used alone.In this study, we explore whether combination of cytokine-induced killer (CIK) adoptive immunotherapy with oncolytic adenovirus-mediated transfer of human interleukin-12 (hlL-12) gene induce the enhanced antitumor potency.Our results showed that oncolytic adenovirus carrying hIL-12 (AdCN205-ILl2) could produce high levels of hIL-12 in liver cancer cells, as compared with replicationdefective adenovirus expressing hIL-12 (Ad-IL12).
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