Combined Therapy with Cytokine-induced Killer Ceils and Oncolytic Adenovirus Expressing IL-12 Induce

来源 :2013第六届世界癌症大会 | 被引量 : 0次 | 上传用户:limingxing0623
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Both adoptive immunotherapy and gene therapy hold a great promise for treatment of malignancies.However, these strategies exhibits limited anti-tumor activity, when they are used alone.In this study, we explore whether combination of cytokine-induced killer (CIK) adoptive immunotherapy with oncolytic adenovirus-mediated transfer of human interleukin-12 (hlL-12) gene induce the enhanced antitumor potency.Our results showed that oncolytic adenovirus carrying hIL-12 (AdCN205-ILl2) could produce high levels of hIL-12 in liver cancer cells, as compared with replicationdefective adenovirus expressing hIL-12 (Ad-IL12).
其他文献
Retinoblastoma has a long history of contributions to cancer biology, inspiring Knudsons two-hit hypothesis of oncogenesis and the cloning of the first tumor suppressor, RB1.By studying retinoblastoma
会议
Telomerase activation is a key step in the development of human cancers.In this study Artificial zinc finger protein (ZFP) transcription factors (TF) was used to repress expression of hTERT in human c
会议
Cancer and other rapidly proliferating cells require cholesterol and other membrane components to optimize growth.High density lipoprotein (HDL) have been implicated in cholesterol delivery in some ma
会议
Gene therapy and oncolytic viral therapy are studied separately and their international conferences are also held separately.We combined them together to initiate the strategy "Cancer Targeting GeneVi
会议
Cancer stem cells (CSCs) are considered to play important roles in tumor initiation, progression, metastasis, and recurrence.However, separation and long-term culture of CSCs remain technical problems
会议
Since the first tyrosine kinase inhibitor (Gleevec) was approved by FDA for treatment of CML, targeted tumor therapy has successfully opened an new avenue for the treatment of the cancer diseases.Such
会议
Due to low expression of coxsackie-adenovirus recptor (CAR) in leukemia cells, the utility of type 5 adenoviruses (Ad5) in leukemic treatment is limited.We constructed recombinant sCAR-ligand fusion p
会议
An attractive strategy among adenovirus-based oncolytic systems is to design adenoviral vectors to express pro-apoptotic genes, in which this gene-virotherapy approach significantly enhances tumor cel
会议
The cadre of individuals living after a diagnosis of cancer is growing steadily.As many as 78% of pediatric patients and 60% of adult patients are alive five years following diagnosis where access to
会议
Traditionally cancer therapy depends on surgery, chemotherapy and radiotherapy.Unfortunately, however, these conventional strategies do not work well in many cases.The examples include that surgery fa
会议