【摘 要】
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Tree shrew(Tupaia belangeri),more closely related to primates than rodents,has been regarded as a promising model to study on stress-related disorders.But the mechanism underlying the susceptibility t
【机 构】
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Department of Neurology and Neurophysics,School of Life Science,University of Science and Technology
【出 处】
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第九届海内外华人神经科学家研讨会(The 9th Symposium for Chinese Neuroscientis
论文部分内容阅读
Tree shrew(Tupaia belangeri),more closely related to primates than rodents,has been regarded as a promising model to study on stress-related disorders.But the mechanism underlying the susceptibility to stress still remains unknown.In our study,the sequence of full length CRH gene of Chinese tree shrew was resolved by genome walking,which showed a high homology of 83%with human CRH gene in coding sequence region and 73%identity in full length.Compared with human CRH peptide,a single amino acid change was found in tree shrew CRH peptide.Similar to human CRH,synthetic tree shrew CRH peptide was capable to induce MAPK pathway activation,POMC transcription and ACTH release,but did not show obvious difference in the above aspects.In the promoter activity analysis,an active GRE site in CRH gene promoter region was identified as a key element responsible for higher promoter activity in tree shrew than that of human under the basal condition or treatment with forskolin and/or dexamethasone.Our results highlight a critical role of the active GRE site through binding with Glucocorticoid receptor in regulating CRH mRNA expression,which contributes to higher promoter activity and susceptibility to stress in tree shrew than in human.(201 words).
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