【摘 要】
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Background: Pigs share many physiological,biochemical,and anatomical similarities with humans and have emerged as valuable large animal models for biomedica
【机 构】
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LaboratoryofAnimalCloning,SouthChinaInstituteforStemCellBiologyandRegenerativeMedicine,GuangzhouInst
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Background: Pigs share many physiological,biochemical,and anatomical similarities with humans and have emerged as valuable large animal models for biomedical research.Considering the advantages in immune system resemblance,suitable size,and longevity for clinical practical and monitoring purpose,SCID pigs bearing dysfunctional RAG could serve as important experimental tools for regenerativemedicine,allograft and xenograft transplantation,and reconstitution experiments related to the immune system.In this study,we report the generation and phenotypic characterization of RAG1 and RAG2 knockout pigs using transcription activatorlike effector nucleases.
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