Hypertension is a major risk factor for cardiovascular diseases, stroke and renal failure.The pathogenesis of hypertension involves genetic and environment factors, as well as the interaction between two factors.It is well documented that intracellular Ca2+ ([Ca2+]i) homeostasis is important for vascular function and blood pressure regulation as well as hormone secretion.Disturbance of [Ca2+]i homeostasis has been determined in both experimental and human hypertension.Because of their unique roles in mediating [Ca2+]i concentration and vascular function, a novel class of non-selective cation channels, called transient receptor potential (TRP) channels, have emerged in the field of hypertension research.Members of the transient TRP channel superfamilies are present in vascular smooth muscle cells and play important roles in the regulation of vascular contractility and blood pressure.