【摘 要】
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Objective: To explore the influence of the cell cycle regulation protein cyclin A and CDK2 expression induced by vinyl chloride monomer (VCM) on HL-7702, one of human normal liver cells, and possible
【机 构】
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Department of Toxicology, School of Public Health, Shanxi Medical University Taiyuan 030001, China
【出 处】
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3rd Asian Conference on Environmental Mutagens & 15th Confer
论文部分内容阅读
Objective: To explore the influence of the cell cycle regulation protein cyclin A and CDK2 expression induced by vinyl chloride monomer (VCM) on HL-7702, one of human normal liver cells, and possible carcinogenic mechanisms of VCM.Methods: HL-7702 cells were exposed to VCM (volume fraction were 0.8%, 2.5%, 7.5%, 15% and 30% respectively) and air (control group) for 48h.The level of cyclin A and CDK2 protein expression were detected by western blotting.Results: Cyclin A and CDK2 protein expression increased following the increase VCM concentration, and the differences compared with 15%, 30% VCM groups and the control group were statistically significant (P<0.05).Conclusion: VCM raised cyclin A and CDK2 protein expression which may disturb the normal cell cycle control.
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