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Aims To evaluate the relationship between platelet activation and liver damage in patients receiving hematopoietic stem cell transplantation (HSCT).Methods P-selectin expression was measured by flow cytometry, liver function (level of alanine transaminase (ALT), totalbilirubin (TBIL)) was evaluated by Bio-Chemical Analyzerand pathology changes of liver sinusoid endothelial cell (LSEC) was assessed byH&E, immunohistochemical and Mason staining.