论文部分内容阅读
Objective: Nuclear receptor coactivator-3 (NCOA3) is a member of the steroid receptor coactivator family that modulates estrogen receptor alpha (ER α) activity to promote proliferation and differentiation in human osteoblasts.An association was found between NCOA3 alleles and lumbar spine bone mineral density (LS-BMD) in Caucasian men,but the relation between NCOA3 and bone metabolism in postmenopausal women (PMW) remains unknown.Current study is to investigate the levels of serum NCOA3 in PMW and their association with BMD and bone turnover markers.Design and Methods: Fifty-eight PMW with osteopenia or osteoporosis and nineteen healthy PMW were recruited into this study.LS-BMD and femoral neck BMD (FN-BMD) were measured by DEXA.Levels of serum NCOA3 and other biochemical variables were assayed.Osteoporosis and osteopenia were diagnosed according to the World Health Organization criteria.Results: The levels of serum NCOA3 in PMW with osteopenia or osteoporosis were remarkably lower than that in healthy individuals (p<0.001 for both).Serum NCOA3 levels were negatively correlated with bone loss severity (p<0.001).Furthermore,serum NCOA3 levels were significantly associated with BMI (p=0.001) and LS-BMD (p=0.013).In multiple regression analyses,only BMI (β =0.311,p=0.014) and LS-BMD (β =0.275,p=0.028) were independent predictors of serum NCOA3 levels.Conclusion: Serum NCOA3 levels are lower in PMW with osteopenia or osteoporosis and have a positive correlation with LS-BMD.NCOA3 can serve as a biochemical marker for determining bone loss severity.Further studies are needed to elucidate the role of NCOA3 in bone metabolism.