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目的:探讨肿瘤放或化疗配合局部热疗对肿瘤治疗的效果。方法:6年中放疗配合局部热疗治疗688例,其中深部热疗443例,浅部165例,放+化+深部80例。化+热120例。热疗采用徐州诺万生产的深部(433MHz)、浅部(915MHz)热疗机,每例病人最少热疗4次,最多者12次,每次热疗时间40～60分钟,温度在38.5-41.5℃之间。放疗采有6～8MV-X线(普放、适形或调强放疗)或电子线照射。化疗根据病种选择化疗方案,最少一个周期,最多4个周期,放+化+热者,化疗一般用二个周期。结果:放+深部热疗有效率在71～91%之间。放+浅部热疗有效率86～96%之间。放+化+深部热疗有效率75～100%之间。化疗配合深部热疗有效率57.5%。结论:结果显示放疗配合热疗或放+化+热疗的有效率多在80%以上,放疗+热疗的治疗效果明显高于单纯放疗的效果,结论是肯定的。单纯化疗配合局部热疗的有效率只有57.5%明显低于放疗+热疗的效果,可能与全身化疗局部病灶药物浓度低或耐药有关。
Objective: To investigate the effect of tumor radiotherapy or chemotherapy combined with local hyperthermia on tumor therapy. Methods: 6 years of radiotherapy with local hyperthermia treatment of 688 cases, of which 443 cases of deep hyperthermia, shallow 165 cases, radiotherapy plus deep 80 cases. + 120 cases of heat. Hyperthermia Xuzhou Novartis deep (433MHz), shallow (915MHz) hyperthermia machine, each patient at least four times hyperthermia, up to 12 times, each hyperthermia time 40 to 60 minutes, the temperature at 38.5- 41.5 ℃ between. Radiotherapy with 6 ~ 8MV-X line (universal, conformal or IMRT) or electronic line irradiation. Chemotherapy Select the chemotherapy based on the type of disease, at least one cycle, up to 4 cycles, release + heat +, chemotherapy with two cycles. Results: Radiotherapy + deep hyperthermia efficiency between 71 ~ 91%. Put + shallow hyperthermia efficiency of 86 to 96%. Radiotherapy + deep hyperthermia efficiency of 75 to 100%. Chemotherapy with deep hyperthermia effective rate of 57.5%. Conclusion: The results showed that radiotherapy combined with hyperthermia or radiotherapy + hyperthermia more than 80% efficiency, radiotherapy + hyperthermia treatment was significantly higher than the effect of radiotherapy alone, the conclusion is affirmative. The effective rate of chemotherapy with local hyperthermia was only 57.5%, which was significantly lower than that of radiotherapy + hyperthermia, which may be related to the low drug concentration or drug resistance of local chemotherapy in systemic chemotherapy.