EIAV(马传贫)病毒与HIV病毒同属于逆转录病毒科慢病毒属,马传贫弱毒疫苗是目前世界上唯一成功应用的慢病毒疫苗,对于该疫苗作用机制的阐明将为艾滋病疫苗的研究提供借鉴.在基础研究和临床检测中,病毒载量的定量分析至关重要,以往对EIAV的检测方法有基于探针的荧光定量PCR,敏感特异,但价格昂贵;还有的方法因需要感染细胞或者测量量子点发射峰等,使得操作技术要求高、实验时间长而未得到广泛的应用,因此,急
TRAF family member-associated NF-κB activator (TANK) is a negative regulator of canonical NF-κB signaling in the Toll-like receptor (TLR)-and B-cell receptor (BLR)-mediated signaling pathways.However,
Oxidative stress has been reported to induce the activation of signal transducer and activator of transcription 3(STAT3),which plays an important role in hepatocellular carcinoma(HCC).We have previous
There is limited information about the role of cervical epithelial cells in genital innate immunity against herpes simplex virus type 2(HSV-2)infection.We thus examined whether human cervical epitheli
Background: The Bowman-Birk inhibitor(BBI)is a soybean-derived protease inhibitor that has anti-inflammatory effect in both in vitro and in vivo systems.Inflammation and immune activation are believed
Bluetongue virus(BTV),a nonenveloped double-stranded RNA virus,is a potent inducer of type Ⅰ interferons in multiple cell systems.In this report,we present that BTV16 treatment of primary human macrop
Introduction: HIV-induced chronic immune activation contributes to CD4+ T ceils depletion and drives progression to HIV disease.However,the direct causal link between chronic immune activation and CD4
丙型肝炎病毒(HCV)在全球总共造成约3％的人慢性感染,但其治疗方案仍然很局限.目前,没有一种预防性或治疗性的疫苗可以控制HCV的传播.先前的研究发现,HCV特异性的T细胞反应对于病毒的清除至关重要.本项目中,我们利用HCV-1b亚型的共有序列,设计了一组能够覆盖HCV全长基因组的交叉重叠的多肽序列,并以此来研究不同类型病人HCV特异性T细胞反应.
More and more studies showed that gut microbiota mediates innate immunity and plays important role as immune-regulator during HBV infection.Therefore,we hypothesize that flagellin,as a key PAMP of gut
Understanding the mechanism of protective antibody recognition against highly pathogenic avian influenza A virus H5N1 in humans is critical for the development of effective therapies and vaccines.Here