Synthesis of OAADPR Analogs and their Inhibitory Activities to Human SirtuinHomolog SIRT1

来源 :首届糖合成化学青年高峰论坛会议 | 被引量 : 0次 | 上传用户：liuhao0760

【摘要】

：

OAADPR(O‐Acetyl‐ADP‐Ribose) is a metabolite product of nicotinamide adenine dinucleotide(NAD+)‐dependent enzymes,histone deacetylases,named as Sirtuins as w

【作者】

：

Zhimeng Wu Brett M.Hirsch Peter C.Tyler Vern L.Schramm

【机构】

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KeyLaboratoryofCarbohydrateChemistry&BiotechnologyMinistryofEducation,SchoolofBiotechnology,Jiangnan

【出处】

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首届糖合成化学青年高峰论坛会议

【发表日期】

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2015年4期

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OAADPR(O‐Acetyl‐ADP‐Ribose) is a metabolite product of nicotinamide adenine dinucleotide(NAD+)‐dependent enzymes,histone deacetylases,named as Sirtuins as well,which play important roles in gene silencing,metabolism regulation,lifespan extension and other cellular processes.

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Synthesis of OAADPR Analogs and their Inhibitory Activities to Human SirtuinHomolog SIRT1

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