Inflammatory response plays an essential role in control of viral infections.However,impairment of regulatory circuits of the inflammatory response often leads to tissue damage in both acute and persistent infection.In this talk,I will discuss the new regulatory mechanisms of how innate inflammatory response of NK and NKT cells is regulated,in infections by coronavirus,highly pathogenic influenza virus and hepatitis C virus.I hope these findings would shed a light on better understanding of viral hepatitis and pneumonia.