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Objective:To evaluate the role of pulsatile perfusion in pediatric complicated congenital heart disease patient undergoing open heart surgery with cardiopulmonary bypass.Methods:24 pediatric patients diagnosed with tetralogy of Fallot were divided randomly into two groups,PP (pulsatile perfusion) group 12 cases and NP (non-pulsatile perfusion) group 12 cases.PP patients used modified roll pump pulsatile perfusion during cross clamping period in CPB and NP cases used roll pump flat-flow perfusion during CPB.Blood flow was same in two groups (from 40 to 120ml/(kg.min)).