【摘 要】
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Background: Schizophrenia patients exhibit a wide range of impairments in cognitive functions.Clinically, typical antipsychotics drugs, such as haloperidol (HAL), have limited or even detrimental impa
【机 构】
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Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medici
【出 处】
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中国神经科学学会精神病学基础与临床分会第十届学术会议
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Background: Schizophrenia patients exhibit a wide range of impairments in cognitive functions.Clinically, typical antipsychotics drugs, such as haloperidol (HAL), have limited or even detrimental impact on cognitive functions.In contrast, atypical antipsychotic drugs (AAPs), such as olanzapine (OLZ), have a therapeutic effect on memory function in schizophrenia patients.However, little is known about the cellular and molecular mechanisms of the effect of AAPs on the impairments of cognitive functions.Here, we chose OL7 as tool drug to investigate the mechanisms of AAPs on the changes in memory function in a rat model of schizophrenia.
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