Nucleolin targeting AS1411 aptamer modified pH-sensitive micelles: a dual-functional strategy for pa

来源 :The Third Symposium on Innovative Polymers for Controlled De | 被引量 : 0次 | 上传用户：colossus198201

【摘要】

：

　　Targeted drug delivery coupled with rapid drug release in cytoplasm is a powerful strategy to enhance efficacy and reduce off-target effects of anti-cancer

【作者】

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JinmingZhang;RuieChen;FengqianChen;MeiwanChen;YitaoWang;

【机构】

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State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,U

【出处】

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The Third Symposium on Innovative Polymers for Controlled De

【发表日期】

：

2014年期

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　　Targeted drug delivery coupled with rapid drug release in cytoplasm is a powerful strategy to enhance efficacy and reduce off-target effects of anti-cancer drugs.Herein,we developed a dualfunctional mixed micellar drug delivery system consisting a biocompatible pH-responsive copolymer,D-a-tocopheryl polyethylene glycol 1000-block-poly-(,β-amino ester) (TPGS-b-PBAE or TP) [1],and AS1411 DNA aptamers (Apt) [2] that recognize the over-expressed nucleolin located on plasmamembrane of cancer cells.

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Nucleolin targeting AS1411 aptamer modified pH-sensitive micelles: a dual-functional strategy for pa

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