【摘 要】
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Fractures are a major public health and economic problem because not all fractures heal well or rapidly.N-3 polyunsaturated fatty acids (PUFAs) are beneficial in bone metabolism, but few studies focus
【机 构】
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Department of Orthopedic,The Third Affiliated Hospital of Southern Medical University,Guangzhou 5106
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Fractures are a major public health and economic problem because not all fractures heal well or rapidly.N-3 polyunsaturated fatty acids (PUFAs) are beneficial in bone metabolism, but few studies focus on the effects of n-3 PUFAs on fracture healing.In this study, we investigated the effect of endogenous produced n-3 PUFAs on fracture healing by examing the femur fracture repair process in fat-1 transgenic mice.A closed femoral fracture was created in mice, and the fractures were analyzed using radiographs, soft X-ray, micro-CT and histology, fat-1 mice exhibited accelerated fracture repair when compared with wt mice.Radiographic and histological analysis demonstrated that healing was earlier in fat-1 transgenic than in wt mice (18-21 days versus 21i-28 days post-fracture).Soft X-ray radiographs and micro-CT also showed that the fracture callus in the fat-1 group was remodeled better when compared with controls.Furthermore histological analysis revealed that endogenous n-3 PUFAs promote fracture healing by improving terminal differentiation of endochondral ossification and accelerating remodeling of the calcified callus.In summary, our findings indicate that endogenous produced n-3 PUFAs in fat-1 transgenic mice promote fracture healing and bone remodeling.Therefore, supplementation with n-3 PUFAs represents a new strategy to promote fracture healing.
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