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HeadlinectDNA的由来液体活检临床需求数字化PCR(ddPCR)的临床应用总结临床个体化用药理念血浆游离DNA(ctDNA)的发现1948 First described cell-free nucleic acid in human blood 1994 Mutatad RAS gene fragrnent in cancer patients blood 1996 Microsatellite alterations on cfDNA in cancer patients