Unlike linear RNAs terminated with 5 caps and 3 tails,circular RNAs are covalently closed,single-stranded transcripts.Recently,with the advent of high-throughput sequencing technology together with co
为理解水通道蛋白(aquaporin,AQP)在塔里木兔(Lepus yarkandensis)适应干旱环境中的作用,采用常规 H.E.染色观察了肾脏组织学结构,采用免疫组织化学和免疫印记检测了AQP 在塔里木兔组织中的分布位置及表达,并与家兔进行了比较.结果显示,在肾脏中,AQP1 分布在血管球毛细血管内皮细胞胞质,近端小管直部和髓袢降支细段上皮细胞胞质；AQP2 分布在髓质集合管上皮细胞膜；A
To cope with free-floating and surface-adhesion growth,the planktonic and biofilm phenotypes constitute the integral bacterial life.Biofilms are bacterial exopolymer-enclosed communities.They are main
Paracellular barrier function plays important role in pathogenesis of IBDs,including UC and Crohns disease(CD),and maintain the gut homeo-mstyacs diosw.n Nstream-regulated gene 2(NDRG2)has been report
阿尔茨海默病(Alzheimers disease,AD)是一种神经系统退行性疾病,其病理学特征包括细胞外出现大量老年斑、神经原纤维缠结以及突触和神经元缺失等。老年斑的主要成分是β-淀粉样蛋白(β-amyloid peptide,Aβ),Aβ由其前体物质淀粉样前体蛋白(amyloid precursor protein,APP)经β-分泌酶及γ-分泌酶剪切而成。为探讨17-β-雌二醇(E2)对神经
Zfp281 is a negative regulator of maintaining pluripotency for embryonic stem cells(ESC).However,its role in other cell types is poorly understood.We therefore generated Zfp281 conditional knockout mi
继长链非编码RNA(long non-coding RNA,lncRNA)和微小RNA(microRNA,miRNA)之后,环状RNA(circularRNA,circRNA)作为另一种功能广泛的非编码内源性RNA成为研究热点.circRNA是广泛存在于转录组中的一类闭合环状的RNA分子.早在40前,circRNA就被发现,但一度被认为是转录本加工过程中发生错误剪接而形成的副产品.近年来随着RNA