【摘 要】
：
目的:研究认知正常老年人群不同APOE基因型静息态海马相关记忆网络分布特征,探索APOE基因多态性调控阿尔茨海默病发病风险的神经机制.方法:对129名认知正常老年受试者(ε2携带组36名,ε3纯合子组44名,ε4携带组49名)完成一般资料收集、多维度认知神经心理评估与静息态功能磁共振扫描.采用AFNI软件预处理影像数据并标准化至MNI空间.
【机 构】
：
东南大学神经精神医学研究所,东南大学附属中大医院,210009 Department of Bio
论文部分内容阅读
目的:研究认知正常老年人群不同APOE基因型静息态海马相关记忆网络分布特征,探索APOE基因多态性调控阿尔茨海默病发病风险的神经机制.方法:对129名认知正常老年受试者(ε2携带组36名,ε3纯合子组44名,ε4携带组49名)完成一般资料收集、多维度认知神经心理评估与静息态功能磁共振扫描.采用AFNI软件预处理影像数据并标准化至MNI空间.
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