【摘 要】
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[Objectives]Background: Anomalies of TLR4 signaling at the maternal-fetal interface are involved in the pathogenesis of preeclampsia.Interventions to induce preeclampsia in animals are generally appli
【机 构】
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Drum Tower Clinical Medical College, Nanjing Medical University, Nanjing 210029, China
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[Objectives]Background: Anomalies of TLR4 signaling at the maternal-fetal interface are involved in the pathogenesis of preeclampsia.Interventions to induce preeclampsia in animals are generally applied after critical time of placental development, which maybe a pivotal time point in the development of preeclampsia.Our goal was to generate an animal model of preeclampsia by an ultralow-dose lipopolysaccharides (LPS, a TLR4 agonist) administration on day 5.5 of pregnancy in pregnant rats.
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