【摘 要】
:
Cyclopropane and its derivatives play an important role in the total synthesis of complex compounds, natural products, and theoretically interesting molecules.To our knowledge, there are no examples o
【机 构】
:
Key Laboratory of Jiangxi University for Applied Chemistry and Chemical Biology, College of Chemistr
论文部分内容阅读
Cyclopropane and its derivatives play an important role in the total synthesis of complex compounds, natural products, and theoretically interesting molecules.To our knowledge, there are no examples of the construction of cyclopropane using lewis acid as reagent in the literature.
其他文献
近红外荧光探针是生物体内常用的荧光探针之一,最大吸收和发射波长位于630nm~1200nm的近红外区域,可降低生物基体荧光对检测的干扰[1],很大程度上提高了检测限及灵敏度.吲哚七甲川菁染料是一类由两端吲哚环通过共轭的七甲川链连接而形成的近红外荧光染料,具有溶解性好、最大吸收波长可调范围大、易于合成且稳定性相对较高等特点[2],广泛应用于生物体内药物输送、金属离子检测、肿瘤成像等方面.
In the past two decades, nanopore techniques have been demonstrated as an ultra-sensitive technique for examining biological interactions at the single-molecule level.A wide range of analytes have bee
目前具有过氧化物酶活性的DNAzyme作为信号分子被广泛应用于各种生化分析中.这类DNAzyme是由富含鸟嘌呤的特定序列组成的鸟嘌呤四聚体结构与血红素hemin结合形成.其特定DNA序列主要来源于人工筛选序列或者天然存在的启动子区域或端粒序列.
Advances in the controlled assembly of nanoscale building blocks have resulted in functional devices for nano-optoelectronics, electrochemistry, analytical chemistry,biomedicine, and other fields [1].
Nanopore is a powerful tool for biomolecular detection at single molecule level.[1]When a molecule pass through the nanopore driven by electrophoretic force,the ion flow will be blocked and induce an
本研究探讨了纳米二氧化硅(SiO2)诱导细胞损伤的作用机制.我们用四甲基偶氮唑盐比色法检测了20-nm和50-nm SiO2对人肺腺癌A549细胞存活率的影响;用25、50和100μg·mL-1纳米SiO2处理细胞24 h后,检测细胞内超氧阴离子(O2-·)、羟自由基(·OH)、过氧化氢(H2O2)、一氧化氮自由基(NO·)、活性氧(ROS)、丙二醛(MDA)的含量以及细胞膜ATPase的活性变化
采用离子交联法构建2,6-二甲基-β-环糊精(DM-β-CD)、壳聚糖(CS)、聚乙二醇(PEG)纳米载体,并以紫杉醇(PTX)为模型药,考察了DM-β-CD/PEG/CS系列载药纳米粒在大鼠体内的药动学特性.通过对DM-β-CD/PEG/CS纳米载体理化性质的表征,表明纳米粒外形光滑圆整,粒度可控,zeta电位分布在+16.3~36.7 mV之间;载PTX纳米载体的包封率为85.3%,载药率为4
基于壳聚糖(CS)、聚乙二醇单甲醚(mPEG)通过一步反应法合成聚乙二醇单甲醚-壳聚糖接枝共聚物(mPEG-g-CS),并采用超声法制备mPEG-g-CS自组装纳米胶束.采用嵌二萘荧光探针法测得mPEG-g-CS临界胶束浓度为264.8 μg/ml;在pH4.0~7.0范围内,mPEG-g-CS自组装纳米胶束具有完整的核壳结构,TEM结果表明胶束球形圆整;在水溶液和共溶剂中胶束粒径分别可控在186
高效液相色谱法测定兔血浆中氟比洛芬含量的方法学建立,并用于氟比洛芬酯(FA)脂微球在兔体内药动学研究.采用乙腈溶液沉淀血浆样品蛋白,高速冷冻离心后上清液过滤进样分析.以外标法定量,进行方法学确证试验.我们开展了确立色谱条件,绘制标准曲线,考察日内日间精密度、稳定性与测定方法回收率等方法学工作,以及兔耳缘静脉给药试验等.
A novel carbon Nanofibers-Ni(OH)2 nanoplates (CNFs-Ni(OH)2) nanocomposite was prepared by a simple oil bath of a mixture containing ethylenediamine anhydrous modified CNFs and nickel(Ⅱ) ions using amm