口蹄疫病毒结构蛋白诱导巨噬细胞天然免疫应答的研究

来源 :中国免疫学会第十届全国免疫学学术大会 | 被引量 : 0次 | 上传用户：kaiyuanwu

【摘要】

：

目的：巨噬细胞(MΦ)和树突状细胞(DC)是抗病毒感染的第一线免疫细胞。本室研究发现重组口蹄疫病毒(FMDV)结构蛋白VPl-VP4可通过清道夫受体(SR)抑制DC的天然免疫应答，但对其与MΦ的作用关系尚不清楚。故我们以FMDV VP1-VP4蛋白负载小鼠腹腔巨噬细胞(pMΦ)，检测其细胞因子表达谱，以揭示MΦ抗FMDV的天然免疫作用。

【作者】

：

王蕾郭娇娜焦玉玲王燕张莎莎高云欢李娜李丽敏王家鑫

【机构】

：

河北农业大学 071000

【出处】

：

中国免疫学会第十届全国免疫学学术大会

【发表日期】

：

2015年10期

【关键词】

：

巨噬细胞口蹄疫病毒清道夫受体细胞因子番泻苷

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口蹄疫病毒结构蛋白诱导巨噬细胞天然免疫应答的研究

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