Objectives: In this study,a novel nanoparticle system was designed based on pullulan(PL),dioleoyl phosphoethanolamine(DOPE)and Pluronic F68(PF68)for the delivery of IR-780(a photosensitizer both to PTT and PDT)and paclitaxel(a chemotherapeutic agent),thus hoping to realize the efficient targeted treatment on hepatoma by combining PTT/PDT and chemotherapy.