In the present study,the effects of Ginsenoside Rg1 (Rg1) on 1-methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced dopamineregic neuron degeneration in the substantia nigra (SN) of C57BL6 mice we
老年性痴呆(Alzheimers disease,AD)是常见的中枢神经变性疾病,其确切的病因不清.以往研究线索表明,AD患者基底前脑胆碱能神经元死亡明显,而兴奋性毒性损伤是导致神经元损伤与AD发病的重要因素.本课题采用kainic acid (KA)兴奋性毒性动物模型,给予神经激肽NK1、NK3受体特异性激动剂(septide、senktide),NK3受体拮抗剂(SB218795)干预和Flu
The degradation of aberrantly phosphorylated tau in neurons plays an important role in the pathogenesis of Alzheimers disease (AD).hHrd1 is a newly identified ubiquitin ligase involved in the endoplas
Objective Previously we have demonstrated that cyclothiazide (CTZ) could induce epilepitiform activity in hippocampal neurons both in vitro and in vivo.Here,we further report that CTZ dose-dependently
The first-generation antihistamines are widely prescribed medications to relieve allergic reactions and urticaria by blocking the peripheral histamine H1 receptor.Overdose of these drugs often results
When arbitrary noises at the two ears are correlated,a single noise image is perceived inside the head even if a short interaural interval (IAI) is introduced.This study examined whether this binaural
Prior exposure to a pattern in the visual scene can enhance subsequent recognition of that pattern in many species from honeybees to humans.However,whether prior experience with a visual feature of an
Effects of morphine on acquisition and retrieval of memory have been proven in the avoidance paradigms.In present study,we used a two-trial recognition Y-maze to test the effects of acute morphine and
Monkeys have strong abilities to remember the visual properties of potential food sources for survival in the nature.The present study demonstrated the first observations of rhesus monkeys learning to
共情是指理解他人的情绪和知觉感受的能力,近年来科学家们运用脑成像技术部分进行了大量的研究,部分揭示了其生理机制和认知模型,而关于痛觉共情的研究,更是成为认知神经科学的焦点问题之一。目前关于痛觉共情的数据主要为fMRI成像的结果,由于fMRI技术的条件限制,以及以人类作为被试,其个体差异很难控制,这使得对痛觉共情的神经机制研究很难深入,建立动物模型就被提上日程。而曾经认为,共情是仅存于灵长类动物的一