【摘 要】
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The extracellular concentration of non-adenine-based purines such as guanosine is as high or higher than that of their adenine-based counterpart, adenosine,
【机 构】
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DepartmentofSurgery(Neurosurgery,Neurobiology)HeadofHamiltonNeuroRestorativeGroupMcMasterUniversityC
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The extracellular concentration of non-adenine-based purines such as guanosine is as high or higher than that of their adenine-based counterpart, adenosine, suggesting that they have an important biological role.Indeed, guanosine has been found to have several important effects on cells both in vitro and in vivo.To date, most of the effects described are long term trophic influences-relating to growth, proliferation and survival of cells.Recently we discovered two phenomena mediated by guanosine that have potentially important implications for the biology of the nervous system.First we reasoned that extracellular guanosine, unlike adenosine, would not cause apoptosis.This proved to be the case.
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