IL-13 associated signal pathway plays an important role in schistosomiasis hepatic fibrosis.In this study we tried to investigate the effects of corilagin to ameliorate schistosomiasis hepatic fibrosis through regulating IL-13 associated signal pathway in vitro and in vivo.The cellular model was set up with HSC-T6 cells stimulated by rIL-13 and male Balb/c mice were infected with S.japonicumcercariaeas as the animal model.Liver histological changes were observed with haematoxylin and eosin (HE) staining.Masson staining was employed to observe the change of egg granulomas.Expression of Col Ⅰ and Col Ⅲ were examined with Immunohistochemistry (IHC).Western bolt was employed to detect the JAK-1 and IL13R α 1 protiens.The mRNA expression of Col Ⅰ,Col Ⅲ,IL-13,JAK-1 and IL13R α 1 were tested by quantitative Real-time PCR.We found less inflammatory changes were found in all corilagin groups compared with Model group and Praziquantel group.The mRNA levels of Col Ⅰ,Col Ⅲ,IL-13,JAK-1 and IL13R α 1 in corilagin groups were significantly decreased when compared with the levels in Model group (p < 0.01).JAK-1 and IL-13Rα 1 protein levels were greatly decreased in the corilagin groups compared with Model group (p < 0.01).In conclusion,corilagin could ameliorate schistosomal hepatic fibrosis probably by down-regulating the expression of IL-13 and signal molecules in IL-13 pathway.