Degradation and osteogenic potential of a novel PLA/nano-sized β-TCPscaffolds

来源 :第二十届全国中西医结合骨伤科学术研讨会、第二届中国医师协会中西医结合医师分会骨伤科学术年会、第十九届浙江省中西医结合骨伤 | 被引量 : 0次 | 上传用户:xiaoex11
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  The effect of increasing nano-sized β-tricalcium phosphate (β-TCP) content on the biological performance of polylactic acid (PLA) composite scaffold was investigated by in vitro degradation and in vivo model of heterotopic bone formation.Nano-sized β-TCP was prepared by wet grinding method, PLA/nano-sized β-TCP scaffold with increasing β-TCP (0-50wt %) contents were fabricated by freeze-drying method.The degradation behavior was carried out by determining the microstructure, the change of pH, weight and comprehensive strength in 26 weeks of hydrolysis.The study in vivo was performed by cutting the composite scaffold contain0,10,30,50% β-TCP and pure β-TCP into blocks(Smm × 5mm × 3mm), and then implanting into subcutaneous tissue of back in rabbits after loading recombinant human bone morphine protein-2(rhBMP-2), each rabbit received 4 samples.The in vitro results indicated a marked pH buffering effect as nano-sized β-TCP filler increased, however, comprehensive strength of composite scaffolds decreased significantly.On the other hand the findings in vivo demonstrated that increasing percentage of nano-sized β-TCP to PLA scaffolds enhanced their osteoconductivity.Composite scaffold containing 50% β-TCP possessed a similar biological performance to pure β-TCP in terms of osteoconductivity, but scaffold containing 30% β-TCP exhibited better mechanical properties, which can meet the demand of bone repair in load-bearing site.This supports the potential future application of PLA/30n-β-TCP scaffold as ideal scaffold for bone tissue engineering.
其他文献
本文检验了饮用同一水源的居民从水中摄取相似无机物的假说。采集了109名成年受验者于24小时内全部饮水的重复样品,其中包括为调制饮料而煮沸的水,研究结果表明,受验者每日
  骨筋膜室综合症(Osteofascial compartment syndrome,OCS)即由骨、骨间膜、肌间隔和深筋膜形成的骨筋膜室内肌肉和神经因急性缺血而产生的一系列早期症候群。最多见于前
目的:探索研究妇产超声在绝经后引发阴道出血患者治疗的临床价值作用.方法:节选2018年8月 ~2019年8月我院住院收治的绝经后阴道出血患者60例作为研究对象,结合患者情况进行超
目的:针对翼状胬肉切除术与带自体角膜缘干细胞结膜瓣移植术相结合方法对患者术后眼表修复的影响进行初步探讨.方法:收集100例翼状胬肉患者有关资料,随机将患者平均分为两组,
目的:探讨关节镜下自体股四头肌腱-骨(QT-B)保残重建后交叉韧带(PCL)的手术技巧与临床疗效.方法:2011年1月~2012年3月对17例后交叉韧带损伤的患者在关节镜下利用同种异体髌腱重
会议
一、引言 随着因特网的普及,人们对通信容量的需求在迅速增加。为了满足人们对通信容量不断增长的需求,一些新的通信技术和设备应运而生。密集波分复用技术的诞生大大提高了
目的:分析腹部CT检查在结肠肿瘤性肠梗阻诊断中的应用效果.方法:此次研究随机选取本院2018年2月至2019年2月期间收治的51例结肠肿瘤性肠梗阻患者进行,对所有患者均进行腹部X
【摘 要】膨胀土具有显著的吸水膨胀软化和失水急剧收缩硬裂两种往复变形特性,由于其具有严重的潜在破坏作用,铁路工程在设计施工时往往采用弃土换填,因大量借弃土方造成沿线水土流失、生态环境破坏与土地资源浪费,带来巨大的经济损失,为此提出膨胀土路堤物理处治的技术原理及技术要领供参考选择。  【关键词】膨胀土;特性;物理处治技术原理及技术要领  1.膨胀土的工程特性  膨胀土是指土中粘土矿物成分主要由亲水性
目的:通过电视X线透视吞咽功能检测(videofluoroscopic swallowing study,VFSS),评价舌体与舌根缺损对吞咽功能的影响和吞咽功能恢复的修复重建方式。方法:采用VFSS对健康志
论著:期页 3750个厂矿企业锰中毒调查及病因学的分析研究·····································……(1)1 使用弥雾喷粉机喷施杀虫眯