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AIM To investigate the diagnostic efficiency of apparent diffusion coefficient value(ADC)in differentiating benign from malignant breast lesions at 3.0T Diffusion-weighted imaging with different pair of b value.METHODS Total110 patients with 107 lesions(44 benign and 63 malignant)was selected for our study with five different bvalues 0,400,800,1200 and 1600s/mm2.ADC values were calculated using different pairs of b values.The cut-off ADC values and diagnostic efficiency was evaluated by receiver operating characteristic analysis.