神经生长因子对支气管哮喘模型大鼠气道重塑的影响及其机制

来源 :2014中华医学会呼吸病学年会暨第十五次全国呼吸病学学术会议 | 被引量 : 0次 | 上传用户：jianjiaomylove

【摘要】

：

目的研究神经生长因子在支气管哮喘气道重塑中发挥的作用及其可能机制,为哮喘治疗寻求新的靶点.方法 30只SPF级健康雄性Wisdar大鼠,随机分为健康对照组、哮喘模型维和NGF抗体干预组.健康对照组采用生理盐水致敏和激发,哮喘组采用鸡卵白蛋白(OVA)致敏和激发,干预组造模同哮喘组,但于第6次雾化激发起,激发前3h,先经鼻滴入兔抗大鼠NGFβ抗体.造模完成后采用HE染色观察大鼠气道壁组织学改变,M

【作者】

：

程兆忠范春辉

【机构】

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the affiliated hospital of Qingdao University 266101

【出处】

：

2014中华医学会呼吸病学年会暨第十五次全国呼吸病学学术会议

【发表日期】

：

2014年3期

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神经生长因子对支气管哮喘模型大鼠气道重塑的影响及其机制

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