【摘 要】
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Objective Gastric cancer(GC)is one of the most common malignancies worldwide.Due to the low rate of early detection,most GC patients were diagnosed as advance stages and had poor response to chemother
【机 构】
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Sun Yat-sen University Cancer Center
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Objective Gastric cancer(GC)is one of the most common malignancies worldwide.Due to the low rate of early detection,most GC patients were diagnosed as advance stages and had poor response to chemotherapy.Some studies found that Fumarate hydratase(FH)participated in the DNA damage response and its deficiency was associated with tumorigenesis in some cancers.However,the role of FH in human GC has not yet been investigated,and the expression of FH in GC and its effect on GC treatment are unknown.Miconazole nitrate(MN)is an imidazole antifungal agent approved for the treatment of yeast infections of the skin or vagina and some other applications.Previous investigation showed that miconazole nitrate induces apoptosis via the death receptor 5-dependent and mitochondrial-mediated pathways in human bladder cancer cells as well as colon cancer cells.However,the probable mechanism should be studied.In this study,we investigated the relationship between FH and cisplatin(CDDP)sensitivity in GC cell lines.
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