Stimulation of α2A-adrenoceptors in the medial prefrontal cortex (mPFC) improves working memory performance.This improvement is accompanied by a selective increase in the activity of mPFC neurons during delay periods.However, the cellular mechanisms responsible for this enhanced response are largely unknown.In the present study, we recorded action potential in the pyramidal neurons of mPFC slice, using whole-cell current clamp recording technique.Our results show that stimulation of oα2A-adrenoceptors enhances intrinsic excitability of neurons.