CREB在抑郁症中的作用

来源 :第四届中国药理学会补益药药理专业委员会学术研讨会 | 被引量 : 0次 | 上传用户：xtyygydskf

【摘要】

：

CREB是一种核蛋白,其蛋白单体由341个氨基酸组成.CREB在神经元的发育、再生、突触形成及细胞修复等神经生理活动中起关键性作用,是调节中枢神经系统功能的关键性因子之一.在细胞静息期,CREB以去磷酸化存在,可与DNA结合但无转录活性.磷酸化是CREB活化的关键条件,磷酸化的CREB形成同源二聚体或与CREB家族的其他成员形成异二聚体,使CREB活化,调节靶基因的转录,并且磷酸化的CREB有利于

【作者】

：

陈姣楚世峰陈乃宏

【机构】

：

中国医学科学院北京协和医学院药物研究所,北京,100050

【出处】

：

第四届中国药理学会补益药药理专业委员会学术研讨会

【发表日期】

：

2014年3期

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CREB在抑郁症中的作用

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