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Background In the updated American Association for the Study of Liver Disease (AASLD) guideline 2011 and the guideline of the European Association for the Study of the Liver (EASL) in 2012, contrast-enhanced ultrasound (CEUS) was dropped from the list of diagnostic techniques of cirrhotic nodules, based on the finding that ICC shows similar CEUS features to HCC Although the CEUS features of intrahepatic cholangiocarcinoma (ICC) with cirrhosis have been investigated in recent years, the analyses either lacked comparisons with ICC with normal hepatic background.