【摘 要】
：
The HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) are structurally diverse compounds that act by binding to an allosteric site,approximately 10A from the polymerase active site,causin
【机 构】
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Institute of Medicinal Chemistry, School of Pharmaceutical Science, Shandong University No.44 Wenhua
【出 处】
：
2006中国天津世界艾滋病日科技会议
论文部分内容阅读
The HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) are structurally diverse compounds that act by binding to an allosteric site,approximately 10A from the polymerase active site,causing a distortion of the catalytic aspartate triad.A number of NNRTIs including nevirapine,delavirdine,and efavirenz,are clinically used in combination of chemotherapy for AIDS.However,there are certain factors that restrict the clinical usefulness of these NNRTIs,including drug compatibilities,adverse effects,the emergence of drug-resistant viral strains,and cross resistance.Consequently,discovery and development of novel NNRTIs with new mechanism of action are of paramount importance.
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